Stachydrine chloride
(S)-2-carboxy-1,1-dimethylpyrrolidinium chloride
CAS: 4136-37-2
Molecular Formula: C7H14ClNO2
Stachydrine chloride - Names and Identifiers
Stachydrine chloride - Physico-chemical Properties
| Molecular Formula | C7H14ClNO2 |
| Molar Mass | 179.64 |
| Melting Point | 225°C |
| Specific Rotation(α) | -27 ° (C=2, H2O) |
| Solubility | Soluble in water, methanol, DMSO |
| Appearance | White powder or crystal |
| Color | White to Off-White |
| Merck | 14,8771 |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD21609192 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, water, derived from Motherwort. |
| In vitro study | Intervention of Stachydrine significantly suppresses the level of p-IκB (ser32) protein in the cytosol and NF-κB (p65) protein in the nucleus (P<0.05). Treatment with Stachydrine hydrochloride (50 µM, 200 µM, 500 µM and 1000 µM) noticeably inhibited MCF-7 and T47D cell proliferation in dose- and time-dependent manner. High concentrations (500 µM and 1000 µM) of Stachydrine significantly increased the frequency of both studied cell lines at the G1 phase of cell cycle, suggesting that Stachydrine hydrochloride could cause cell cycle arrest. |
Stachydrine chloride - Risk and Safety
| Risk Codes | R20 - Harmful by inhalation R22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| HS Code | 29339900 |
Stachydrine chloride - Reference
| Reference Show more | 1. Chen Xinmei, Chen Yonggang, 3], et al. Effects of nanosecond pulsed electric field sterilization on contents of stachydrine hydrochloride in motherwort extract and hepatotoxicity in mice [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2018, 020(005):27-30. 2. [IF = 3.373] Na Zhang et al."TLC-MS identification of alkaloids in Leonuri Herba and Leonuri pructus aided by a newly developed universal derivatisation reagent optimised by the response surface method."Phytochem Analysis. 2021 May;32(3):242-251 3. [IF=5.34] Xiaomei Bao et al."Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis."Phytomedicine. 2022 Jun;100:154066 |
Stachydrine chloride - Reference Information
| plant source: | motherwort |
| biological activity | Stachydrine hydrochloride is the main active ingredient of Herba Leonuri and can be used for cardiovascular disease research. Stachydrine hydrochloride can inhibit NF-κB signaling pathway. It has anti-myocardial hypertrophy activity. |
| Target | Value |
| use | stachydrine hydrochloride has the effects of improving coronary artery and myocardial trophic blood flow and reducing myocardial cell necrosis. used for content determination/identification/pharmacological experiments and other pharmacological effects: antitussive, expectorant, antiasthmatic and exciting uterus |
Last Update：2024-04-09 02:00:08
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